I've never tried that (and never would) so this is speculation on my part but I can see two potential problems.
First, the tip of the safety lever that would normally be pushing up on the safety lock (a.k.a., firing pin block) could catch on the hole in the slide where the safety lock should be as the slide cycles causing damage to the safety lever, slide and/or the frame.
Second, and this is more a possibility on a standard reset trigger than an SRT, the safety lever would not be pushed down by the safety lock as the slide comes back into battery (as it normally would) and the trigger mechanism might fail to reset.
In any event, your pistol would be missing an important safety feature, i.e., drop safety. Either way, hardly worth the risk.