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I guess, it would depend if it's M16(AR-15) Mil-Spec, as far as manipulating the trigger assembly. Most AR ambidextrous safeties have the left side as standard GI lever, and a "bolt-on" right side lever. From the looks of the examples of 516s on Sigs web site, it is hard to tell how the right levers are attached.
A "close-up" photo of both sides may help, and from above with the upper removed...
A "close-up" photo of both sides may help, and from above with the upper removed...